News
| 10.2025 | Press release: "Flexibility is function: How unstructured protein segments regulate biological functions" Read the article from the Leipzig University Magazine here. | |
| 11.2024 | Our work "A Generic Residue Numbering Scheme for the GAIN Domain of adhesion G protein-coupled receptors" has just been accepted for publication in Nature Communications. The GAIN domain is a hotspot for pathological mutations. However, the low primary sequence conservation of GAIN domains has thus far hindered the knowledge transfer across different GAIN domains in human receptors as well as species orthologs. To overcome this obstacle, we developed the GAIN-GRN scheme in collaboration with the David Gloriam Laboratory at Copenhagen University that enables researchers to generate hypothesis and rationalize experiments related to GAIN domain function and pathology. | |
| 10.2024 | Article accepted in Nature Reviews Drug Discovery "Functional dynamics of G protein coupled receptors reveal new routes for drug discovery" by Vittorio Limongelli, Paolo Conflitti, Ed Lyman, Mark Sansom, Hugo Guitérrez-de-Terán, Paolo Carloni, Bertie Ansell, Shuguang Yuan, Patrick Barth, Anne Robinson, Peter Hildebrand, Matthew Eddy, Scott Prosser, Stephan Grzesiek, David Gloriam, Christopher G. Tate, and Vittorio Limongelli. | |
| 06.2024 | Our article: "mechanistic insights into G-protein coupling with an agonist-bound G-protein-coupled receptor" hast been accepted at the journal nature structural & molecular biology. Here to the publication |
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| 02.2024 | Our collaborative work with Yiorgo Skiniotis lab has just been accepted by NATURE you'll find the preprint here |
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| 06.2023 | Press release: Novel TRENDS Article on aGPCRs out! 7TM domain structures of adhesion GPCRs: what's new and what's missing? Seufert, F., Chung, Y. K., Hildebrand, P. W., Langenhan, T. Trends in Biochemical Sciences (2023) Here to the publication |
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| 05.2023 | Pressemitteilung: Das Leipziger Universitätsmagazin: "Neue digitale Werkzeuge, um das Beste aus beiden Welten miteinander zu verbinden" Wie zwei Top-Wissenschaftler die Wirkungsweise von Rezeptoren erforschen Hier zum Artikel des Leipziger Universitätsmagazin |
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| 03.2023 | We proudly announce the release of our new website MutationExplorer. | 
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