An interactive tool for prediction, visualization and selection of missing segments in proteins

SuperLooper2 is an interactive web service for the insertion of missing segments such as loops in proteins. Loop candidates are selected from a pre-calculated database containing ~700 million protein fragments with a residue length of 3-35. The fragments are extracted from structural coordinates deposited in the RSCB PDB [1].


The integration of the NGL viewer [2], a molecular viewer based on WebGL, allows visualization and interactive selection of a loop from a list of 100 suitable candidates. A color code is provided to indicate clashes or other relevant criteria to promote an individual choice of the most suitable loop.


A selected loop can be downloaded inserted into the user provided protein. In addition, all 100 loop candidates can be downloaded for further analyses.