Professor Peter W. Hildebrand

Leipzig Universität Leipzig Medizinische Fakultät Institut für Medizinische Physik und Biophysik Room: 251 Härtelstr. 16-18 04107 Leipzig Mail: peter.hildebrand@medizin.uni-leipzig.de Telephone: +49 (0) 341 97-15712 Telefax: +49 (0) 341 97-15709

Education and Training

1989 - 1992	Studies in biology, University of Regensburg
1991	Pree-degree in biology
1993 - 1994	Studies in biology/ecology, University of Sevilla, Spain
1994	Two months practicum at the Institute of Natural and Nutritional Science of Sevilla, Spain
1995 - 1997	Studies of Biology, University of Regensburg, final examination in 1997
1997 - 1998	Diploma Thesis at the Ecological Faculty of Humboldt University Berlin
1998	Awarded Diploma in Biology by Humboldt University Berlin
1999 - 2002	PhD Student at the graduate college "Model Studies of Structure, Behaviour and Recognition of Biomolecules in Atomic Resolution"
2003	Awarded the title "Doktor rerum naturalium" (Dr. rer. nat.) by Humboldt University Berlin. Title of the Dissertation Thesis: Tertiary Structure Modelling of Helical Membrane Proteins"
2008 - 2011	Habilitation Dissertation Thesis: Structure-Function Relationships of Helical Membrane Proteins: Implications for 3D Modelling"
2011	Habilitation in Biophysics at Charité Universitätsmedizin Berlin
2010 - 2012	Advanced education in the ESF qualifying Programme for teaching

Academic Positions

2003 - 2005	Post-doctoral fellow at the Institute of Biochemistry, Humboldt University Berlin in the Protein Structure Theory Laboratory of Prof. Dr. Cornelius Frömmel
2005 - 2007	Post-doctoral fellow at the Institute of Molecular Biology and Bioinformatics of the Free University Berlin, in the Structural Bioinformatics Laboratory of PD Dr. Robert Preißner
2008 - 2017	Head of the ProteinFormatics laboratory at the Institute of Medical Physics and Biophysics, Charité Universitätsmedizin Berlin
2009 - 2010	Guest scientist at the Los Alamos National Laboratory, New Mexico, U.S.A.
2017 - 2013	Guest Professor at the Institute of Medical Physics and Biophysics, Charité Universitätsmedizin Berlin. Co-PI with BIH Einstein Visiting Fellow Prof. Dr. Brian Kobilka ,Stanford University, of the Project "in silico GPCR"
2017 - dato	Professor at the Institute for Medical Physics and Biophysics, Leipzig University

Selected Publications

1.	Papasergi-Scott MM, Pérez-Hernández G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G. Time-resolved cryo-EM of G-protein activation by a GPCR. Nature.024 Mar 13. doi: 10.1038/s41586-024-07153-1.
2.	Batebi H, Pérez-Hernández G, Rahman SN, Lan B, Kamprad A, Shi M, Speck D, Tiemann JKS, Guixà-González R, Reinhardt F, Stadler PF, Papasergi-Scott MM, Skiniotis G, Scheerer P, Kobilka BK, Mathiesen JM, Liu X, Hildebrand PW.Mechanistic insights into G-protein coupling with an agonist-bound G-protein-coupled receptor. Nat Struct Mol Biol. 2024 Jun 12. doi: 10.1038/s41594-024-01334-2. Online ahead of print. PMID: 38867113.
3.	Kampfrath M, Staritzbichler R, Hernández GP, Rose AS, Tiemann JKS, Scheuermann G, Wiegreffe D, Hildebrand PW. MDsrv: visual sharing and analysis of molecular dynamics simulations. Nucleic Acids Res. 2022 Jul 5;50(W1):W483-W489. doi: 10.1093/nar/gkac398.
4.	Beliu G, Altrichter S, Guixà-González R, Hemberger M, Brauer I, Dahse AK, Scholz N, Wieduwild R, Kuhlemann A, Batebi H, Seufert F, Pérez-Hernández G, Hildebrand PW, Sauer M*, Langenhan T*. Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain. Mol Cell. 2021 Mar 4;81(5):905-921.
5.	Tiemann JKS, Guixà-González R, Hildebrand PW, Rose AS*. MDsrv: viewing and sharing molecular dynamics simulations on the web. Nat Methods. 2017 Nov 30;14(12):1123-1124.
6.	Rose AS, Hildebrand PW. NGL Viewer: a web application for molecular visualization. Nucleic Acids Res. 2015 Jul 1;43(W1):W576-9.
7.	Rose AS, Elgeti M, Zachariae U, Grubmüller H, Hofmann KP, Scheerer P, Hildebrand PW.Position of transmembrane helix 6 determines receptor G protein coupling specificity. J Am Chem Soc. 2014 Aug 13 ;136(32):11244-7.
8.	Scheerer P, Heck M, Goede A, Park JH, Choe HW, Ernst OP, Hofmann KP, Hildebrand PW. Structural and kinetic modeling of an activating helix switch in the rhodopsin-transducin interface. Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10660-5.
9.	Hildebrand PW, Goede A, Bauer RA, Gruening B, Ismer J, Michalsky E, Preissner R. SuperLooper- - a prediction server for the modeling of loops in globular and membrane proteins. Nucleic Acids Res. 2009 Jul;37(Web Server issue):W571-4.
10.	Scheerer P, Park JH, Hildebrand PW, Kim YJ, Krauss N, Choe HW, Hofmann KP, Ernst OP. Crystal structure of opsin in its G-protein-interacting conformation. Nature. 2008 Sep 25;455(7212):497-.