Professor Peter W. Hildebrand

Charité – Universitätsmedizin Berlin
Charitéplatz 1 (internal: Virchowweg 11)
10117 Berlin
Telephone: +49 30 450 524 190
Telefax: +49 30 450 524 952

Universität Leipzig
Medizinische Fakultät
Institut für Medizinische Physik und Biophysik
Room: 251
Härtelstr. 16-18
04107 Leipzig
Telephone: +49 (0) 341 97-15712
Telefax: +49 (0) 341 97-15709

Education and Training

1989 - 1992 Studies in biology, University of Regensburg
1991 Pree-degree in biology
1993 - 1994 Studies in biology/ecology, University of Sevilla, Spain
1994 Two months practicum at the Institute of Natural and Nutritional Science of Sevilla, Spain
1995 - 1997 Studies of Biology, University of Regensburg, final examination in 1997
1995 - 1997 Studies of Biology, University of Regensburg, final examination in 1997
1997 - 1998 Diploma Thesis at the Ecological Faculty of Humboldt University Berlin
1998 Awarded Diploma in Biology by Humboldt University Berlin
1999 - 2002 PhD Student at the graduate college "Model Studies of Structure, Behaviour and Recognition of Biomolecules in
Atomic Resolution"
2003 Awarded the title "Doktor rerum naturalium" (Dr. rer. nat.) by Humboldt University Berlin.
Title of the Dissertation Thesis: Tertiary Structure Modelling of Helical Membrane Proteins"
2008 - 2011 Habilitation Dissertation Thesis: Structure-Function Relationships of Helical Membrane Proteins: Implications for 3D
2011 Habilitation in Biophysics at Charité Universitätsmedizin Berlin
2010 - 2012 Advanced education in the ESF qualifying Programme for teaching

Academic Positions

2003 - 2005 Post-doctoral fellow at the Institute of Biochemistry,
Humboldt University Berlin in the Protein Structure Theory Laboratory of Prof. Dr. Cornelius Frömmel
2005 - 2007 Post-doctoral fellow at the Institute of Molecular Biology and Bioinformatics of the Free University Berlin,
in the Structural Bioinformatics Laboratory of PD Dr. Robert Preißner
2008 - 2017 Head of the ProteinFormatics laboratory at the Institute of Medical Physics and Biophysics,
Charité Universitätsmedizin Berlin
2009 - 2010 Guest scientist at the Los Alamos National Laboratory, New Mexico, U.S.A.
2017 - dato Guest Professor at the Institute of Medical Physics and Biophysics, Charité Universitätsmedizin Berlin.
Co-PI with BIH Einstein Visiting Fellow Prof. Dr. Brian Kobilka ,Stanford University, of the Project "in silico GPCR"
2017 - dato Professor at the Institute for Medical Physics and Biophysics, Leipzig University


2016 ‘secundo loco’ W2 professorship for computer simulations at University Leipzig.

Selected Publications

1. Szczepek, M., Beyrière, F., Hofmann, K. P., Elgeti, M., Kazmin, R., Rose, A., Bartl, F. J., Stetten von, D., Heck, M., Sommer, M. E., Hildebrand, P. W. and Scheerer, P (2014). Crystal structure of a common GPCR binding interface for G protein and arrestin, Nat. Commun., 10, 4801.
2. Rose A.S., Elgeti M., Zacchariae U., Grubmüller H., Hofmann K.P., Scheerer P. and Hildebrand P.W. (2014) Position of transmembrane helix 6 determines receptor g protein coupling specificity.J Am Chem Soc, 32, 11244-7.
3. Budkevich T.V., Giesebrecht J., Ramrath D., Mielke T., Ismer J., Hildebrand P.W., Tung C.S., Nierhaus K.H., Sanbonmatsu K.Y. and Spahn C.M.T. (2014) Regulation of the mammalian elongation cycle by 40S subunit rolling: a eukaryotic-specific ribosome rearrangement, Cell, 1, 121-31.
4. Elgeti M., Rose A.S., Bartl F.J., Hildebrand P.W., Hofmann K.P. and Heck M. (2013) Precision vs. flexibility in GPCR signalling. J Am Chem Soc, 33, 12305-12.
5. Munter L.M., Sieg H., Bethge T., Liebsch F., Bierkandt F.S., Schleeger M., Bittner H.J., Heberle J., Jakubowski N., Hildebrand P.W., Multhaup G. (2013) Model peptides uncover the role of the BACE1 transmembrane sequence in metal-ion mediated oligomerization, J Am Chem Soc, 51, 19354-61.
6. Richter, L., Munter, L.M., Ness, J., Hildebrand, P.W., Dasari, M., Unterreitmeier, S., Bulic, B., Beyermann, M., Gust, R., Reif, B. et al. (2010) Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization. Proc Natl Acad Sci U S A, 107, 14597-14602.
7. Hildebrand, P.W., Scheerer, P., Park, J.H., Choe, H.W., Piechnick, R., Ernst, O.P., Hofmann, K.P. and Heck, M. (2009) A ligand channel through the G protein coupled receptor opsin. PLoS ONE, 4, e4382.
8. Scheerer, P., Heck, M., Goede, A., Park, J.H., Choe, H.W., Ernst, O.P., Hofmann, K.P. and Hildebrand, P.W. (2009) Structural and kinetic modeling of an activating helix switch in the rhodopsin-transducin interface. Proc Natl Acad Sci U S A, 106, 10660-10665.
9. Scheerer, P., Park, J.H., Hildebrand, P.W., Kim, Y.J., Krauss, N., Choe, H.W., Hofmann, K.P. and Ernst, O.P. (2008) Crystal structure of opsin in its G-protein-interacting conformation. Nature, 455, 497-502.
10. Hildebrand, P.W., Rother, K., Goede, A., Preissner, R. and Frommel, C. (2005) Molecular packing and packing defects in helical membrane proteins. Biophys J, 88, 1970-1977.